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> Administration of Vaginal Progesterone Effect on Implantation Rates in Embryo Recipient
> Relationship Between Sperm Survival Assay Results Performed forQC of Plastic Cultureware and IVF
> Paternal Factors Predict Increased Rates of Aneuploidy in Egg Donor Cycles
> Use of GnRH Antagonists in Egg Donation Cycles
> Aneuploidy Rates In Young Egg Donors Related To Presence of Male Factor
> No Effect of IVF on Singleton Birth Weight and Pre-term Delivery Rate in Oocyte Donation Cycles
> Sperm DNA Damage as Measured by SCSA Does Not Predict Sperm Survival Rate
> Response to COH Does not Correlate with Singleton Birth Weight in Oocyte Donation Cycles
> High Sperm DNA Fragmentation are Predictive of Poor Outcome in Egg Donation
> Effect of Medications on Semen Analysis and SCSA
> Cryopreservation No Effect on Implantation and Pregnancy Rates in Egg Donation
> Surrogacy Enhances Implanatation Rates in Egg Donation
> ICSI of Testicular Sperm Results in Higher Fertilization Rates than Ejaculated Sperm
> Activation of Human Oocytes using Calcium Ionophore After ICSI Increases Fertilization
> Insemination of Oocytes by IVF or ICSI does not Reduce Fertilization Rates
> Surrogacy Enhances Pregnancy and Implantation Rates in Fresh and Frozen Embryo Transfers
This research presented at the American Society for Reproductive Medicine (ASRM), Philadelphia, 2004..
CA Adams, LS Anderson and SH Wood. Reproductive Sciences Center, La Jolla, CA, USA.
Objective: The DNA Fragmentation Index (DFI), as measured by the Sperm Chromatin Structure Assay (SCSA), has been shown in several studies to be an independent predictor of male fertility potential in ART cycles. The DFI describes the percentage of sperm with DNA fragmentation, that fragmentation being the result, hypothetically, of faulty DNA repair mechanisms. It has been proposed that high quality oocytes may have the ability to repair sperm whose DNA has experienced oxidative damage. The purpose of the present study was to explore whether donor eggs are capable of compensating for suboptimal sperm chromatin integrity. .
Design: A retrospective analysis of 50 consecutive egg donor cycles (mean age of donors: 23.6y ± 3.4) in a private IVF clinic.
Materials and Methods: The SCSA was performed on all males undergoing egg donation cycles. Cycles were assigned into one of three groups based on the DFI, as described in previously published studies: Group A (Low DNA fragmentation): <15% (mean: 10.1%, n= 22), Group B (Moderate DNA fragmentation): 15-30% (mean: 22.4, n=19), Group C (High DNA fragmentation): >30% (mean: 47.7%, n = 9). Fertilization rates (2PN), embryo quality, implantation, and pregnancy rates were assessed. For determination of on-going pregnancy and implantation rates, the number of gestational sacs with fetal cardiac activity was evaluated. Data was evaluated for statistical significance utilizing the ANOVA or chi-square as appropriate.
Results: There was no significant difference in the mean number of embryos transferred in each group. Pregnancy and implantation rates were not significantly different between Groups A and B (73% vs. 74% and 31% vs. 30%). However, Group C had a significantly lower pregnancy rate (22%, p<0.025) and implantation rate (13%, p<0.025). Fertilization rates were not significantly different among Groups A, B and C (mean 2PN: 77%, 74% and 64%, respectively). Likewise, the percentage of good quality day 2 or 3 embryos (<25% fragmentation) was also not significantly different among the three groups (86%, 86% and 93%, respectively)..
Conclusions: The data indicates that men with high levels of DNA fragmentation (DFI >30%) have significantly lower pregnancy and implantation rates in egg donation cycles, despite no significant difference in fertilization rate or cleavage-stage embryo quality. Thus, the 30% DFI threshold appears to be an important prognostic indicator even in egg donation cycles. However, since there is no apparent deleterious effect on pregnancy or implantation rates of moderate levels of DNA fragmentation (15-30%) when an egg donor is used, it may be that good quality oocytes from young women are able to repair moderate, but not high, levels of sperm DNA damage.
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