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> Administration of Vaginal Progesterone Effect on Implantation Rates in Embryo Recipient
> Relationship Between Sperm Survival Assay Results Performed forQC of Plastic Cultureware and IVF
> Paternal Factors Predict Increased Rates of Aneuploidy in Egg Donor Cycles
> Use of GnRH Antagonists in Egg Donation Cycles
> Aneuploidy Rates In Young Egg Donors Related To Presence of Male Factor
> NoEffect of IVF on Singleton Birth Weight and Pre-term Delivery Rate in Oocyte Donation Cycles
> Sperm DNA Damage as Measured by SCSA Does Not Predict Sperm Survival Rate
> Response to COH Does not Correlate with Singleton Birth Weight in Oocyte Donation Cycles
> High Sperm DNA Fragmentation are Predictive of Poor Outcome in Egg Donation
> Effect of Medications on Semen Analysis and SCSA
> Cryopreservation No Effect on Implantation and Pregnancy Rates in Egg Donation
> Surrogacy Enhances Implanatation Rates in Egg Donation
> ICSI of Testicular Sperm Results in Higher Fertilization Rates than Ejaculated Sperm
> Activation of Human Oocytes using Calcium Ionophore After ICSI Increases Fertilization
> Insemination of Oocytes by IVF or ICSI does not Reduce Fertilization Rates
> Surrogacy Enhances Pregnancy and Implantation Rates in Fresh and Frozen Embryo Transfers
This research presented at the Alpha Society Scientific Meeting, Antwerp, Belgium, 2003
CA Adams, LS Anderson , A. Scroop and SH Wood. Reproductive Sciences Center, La Jolla, CA, USA.
Introduction: Egg donation cycles typically yield excellent pregnancy rates. In some cases, however, a fresh embryo transfer is not advisable for medical (e.g., poor endometrial lining) or practical reasons. The aim of this study was to determine whether cryopreservation exerts a detrimental effect in egg donation cycles in which all embryos are electively frozen.
Materials/Methods: A retrospective analysis of all egg donation cases over a two-year period, 2001-2002. Fresh cycles (n = 71) were compared to elective cryopreservation cycles (n = 10) in which embryos were frozen at the pronuclear or cleavage stage using a modified propanediol/sucrose technique. All recipients underwent the same hormone replacement regimen for endometrial preparation with embryo transfers performed on day 2 or 3.
Results: There were no significant differences between the fresh and cryopreservation groups in age of donors, age of recipients, number of eggs retrieved or fertilization rates. The overall freeze-thaw embryo survival rate was 90% (46/51). Embryo transfers following elective cryopreservation cycles yielded implantation (69%) and pregnancy rates (90%) that compared favorably to fresh embryo transfer cycles (48% and 83% respectively)..
Conclusions: The elective cryopreservation of all embryos in egg donation cycles has no apparent detrimental effect on implantation or pregnancy rates suggesting that this is the optimal strategy for cycles in which fresh transfers are not indicated. Frozen cycles eliminate the need to synchronize donors and recipients thus allowing much greater flexibility in their scheduling. Using embryo cryopreservation to optimize donor and recipient cycles individually may result in enhanced implantation rates.
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